 |
|
|
|
Men's Health | Women's Health | Children's Health | Elder Health Holistic Health | Healthy Heart | Cancer | Weight Loss Exercise & Fitness | Healthy Resources | HOME PAGE Health Club 101 DIRECT Natural Supplements | HGH Energizer | Eazol Natural Pain Relief | Revitol Cellulite Solution IBS Irritable Bowel Syndrome | Menopause Symptoms Relief | Insomnia Sleeping Aid Articles & Information Medicine | Nutrition | Exercise | Fitness Equipment | Pregnancy Bodybuilding Supplements | Weight Loss | Breast Cancer | Diabetes Category Site Map |
 |
Death, Aging, Rejuvenation (Part 1)
I would like to raise a question: Is Rejuvenation possible and how to approach it? This is just my own opinion about possible procedures. I used certain techniques based on a theory. As strange as it sounds some of those techniques and procedures might actually worked. There are several hundreds theories of aging. New and old ones. Different authors classify them differently. I would divide all those theories into 2 groups : 1. Theories of Deterioration from external cause. "Wear and tear". Theory of free radicals damage is most fashionable at present time. Antioxidants are considered a cure. Benefits of caloric restriction are often explained by that theory. The theory has good objective support in scientific literature. Other theories of this group included changes of bacteria in the gut, radiation and accumulation of mutations during life of an individual, etc. - many more of those theories were discussed in the XX century. 2. Internal clock - theories. I would divide the "internal clock" theories into 2 more subgroups: 1. Internal clock on the level of cell. Telomeres shortening is the most discussed in literature at present. 2. Internal clock on the level of organism. Growth hormone changes was a recent example of discussion. Authors are usually very cautious and objective in scientific literature. Telomeres are usually discussed in connection with "immortal" cancer cells. Caloric restriction is discussed as a mean of longevity (not rejuvenation per se). Level of growth hormone (GH) or insulin-like growth factor drops in aged persons. Mass media speculates wider: telomeres restoration - possible immortal life, growth hormone will rejuvenate you, etc. Original scientific studies usually do not speculate about this. In no way for example drop of GH level in elderly means that just giving it back will make you young again. Scientific literature rarely discuss "Rejuvenation" as it is. Authors mostly talk about "longevity". This is very different story. Longevity in a wheelchair is very distinct from a youth playing soccer. One proven method to reach longevity is caloric restriction. Often they say it is the only proven technique. Using antioxidants as a method to prolong life is in the same category. To put simple, the Theory says: nutrition produce products of oxidation - peroxides, etc. These products damage DNA, proteins, etc. Cell ages. Caloric restriction switches metabolic pathways. There are less free radicals. Hence longevity. Antioxidants work in similar way - they remove free radicals. Another speculation is that caloric restriction starting at young age delays reproductive age in animals and this slows down biological clocks and prolongs life until an environment with high nutrition supply is found. Animals look small and undeveloped. Caloric restriction significantly (25%-100% and more) prolonged life in worms, flies, spiders, rats, mice, etc. Experiments on monkeys and humans are under way and will take decades. Well, it is all good in experiments and theories. Some argue: why in this case prisoners of concentration camps do not live longer. Another example came from "Scientific American" - a person had caloric restriction of something 20 years or more - no effect - he just looks like very thin undernourished person of 50 years. Examples of opposite opinion also exist (tribes or groups with low food consumption or high antioxidants consumption have more centenarians than general population). Maybe you really need to start at 10 years of age, look malnourished and weak for the whole life and live to 100 years, getting to your puberty at 25. Antioxidants also bring many controversy. Vitamin E did not show many benefits though it was a big hope for prevention of many diseases of old age. And so on. Today there are big trials that disprove the theory. Tomorrow - great experiments that confirm the theory, at least partially. Many big trials and experiments are published in leading journals - Science, Nature, PNAS, New England JM, JAMA, etc. One bias for caloric restriction experiment in my opinion is following. Rats live in cage 30cmX60cm for their whole life. There are at least five rats or 20 mice. They live couple years and die. During the experiments they are celebrities when they live 5 years - some lucky ones. The Food is a balanced mixture of nutrition. Caloric restriction is - 60% of their regular meal. They practically don't move - there is no space in cage. Mostly they sleep whole day. Sometime they fight and mate. They live in those conditions at Yale, at Med U of South Carolina, at Russian State Medical University and I think everywhere else. To compare our fellow humans we would place 10 people on area of 20 square metres (200 sq. feet) for 50 years in a row, feeding them with what they want but all the same - let say junk food from McDonalds. I remember my cat (who was partially wild) stole meat and ate until it started to vomit. He repeated it many times when he was able to steal some steak or whatever. The same happens in wild - lions have maybe one successful hunt out of ten. When they catch a prey, they eat like crazy. Much more than they can digest at the moment. So it looks like there is an instinct. Eat as much as possible. This is not a joke - 60% of people in western countries are overweight. Abundant high calorie food and lack of activity. It does not seem that for these people any internal mechanism restricts food consumption. Applying this back to rats, we can see that what is considered normal consumption - "ad lib" - maybe actually big overfeeding of the animals in these cages. In this case 60% of caloric restriction would be just what rats need, just what the calories they spend in lazy, uneventful daily life. So called "control", "normal" rats - that fed as they usually fed might be compared for fat overweight humans. They consume junk food. They prone to the bunch of diseases of obesity and low activity. Heart diseases, strokes, variety of cancers, arthritis, etc. In this case all the hype about caloric restriction would just be brought to the business of mere balancing diet and activity in so called "calorie-restricted animals". I haven't seen any discussion of this problem. I might be wrong. This is why I use caloric restriction for myself. I did not work with worms and spiders. But my guess would be that they all are also in artificial standardized conditions. "Control" worms might be also overfed. To put rats into bigger cages (to increase activity in control group and balance calories and catabolism) would be incredibly expensive. Even at present conditions because of "animal lovers" and bunch of other regulations and considerations (e.g. sterile conditions), the price of animal housing is sky-high. You would say animals in wild would live longer because they balance activity and consumption. Well, recently I read that life span of animals in wild is shorter than animals in captivity. Correct me if I am wrong: pandas live 15-20 years in nature and 20-30 in zoos, bears 20-25 in nature and 30-40 in captivity. Civilization has certain benefits - vaccinations, good medical care, more or less good hygiene. So just moving into wild conditions wouldn't make you younger or allow to live longer. Now, to discuss rejuvenation procedures, I would need to talk about aging first. In this case Rejuvenation could be considered as reversal of aging (deterioration). Longevity is different story - it is prolonged life span. Rejuvenation supposedly should lead to longevity. But longevity is not equal to Rejuvenation. Aging leads to Death eventually. It is easier to discuss from that end. All written here is just plain speculation, take it with a grain of salt. - continued in Part 2 About The Author Aleksandr Kavokin, MD,PhD http://www.geocities.com/aging_rejuvenation/ http://www.geocities.com/usmle_test
MORE RESOURCES:
Men's Health
|
Women's
Health |
Children's
Health |
Elder
Health
Medicine - Google News |
|
|
|
RELATED ARTICLES
The Niacin Rush Your face turns flush and your skin starts to itch. Yourheart begins to beat faster. Simple Easy Health and Home Fixes From The Days Gone By How did we cure ourselves of many aches pains and illnesses in the past?Most of the remedies worked very well, were cheap and could usually be found in most homes.Did you know that? Drinking two glasses of Gatorade can relieve headache pain almost immediately, without the unpleasant side effects caused by traditional "pain relievers. The No 1 Reason Why Most Diets Fail & What to Do About It How many times have you tried to diet/lose weight in the past?How many times have you had some initial success only to fallshort of your goals?How many times have you achieved your initial goals, only to seethem fly away faster than you were able to enjoy the fruits ofyour labour?Why does this happen?In most cases, the answer is simple. You've failed one test. Fat: The Good, The Bad, and The Ugly When it comes to planning a healthy diet, fat is a complex subject. It's useful to understand some basic information. Green Tea and Cholesterol Facts A green and lush oasis in the middle of a scorching dessert. A cool breeze on a hot summer night. Chew Your Food I am going to share with you possibly the most important piece of advice you will ever receive about nutrition. This piece of advice is not about supplementation. 5 Ways to Get the Best Out of Radishes They sit left behind on relish trays. They're often by-passed ingrocery store refrigerator shelves. Ultra Refined Fish Oil - The New Generation of Fish Oil Dr. Barry Sears revolutionized nutritional thinking around the world with his 1995 landmark #1 New York Times best seller The Zone. Vegetarian Lifestyle Being vegetarian is one of the greatest things in the world. From good health to sufficient energy in your daily life. Nutritional Myths that Just Wont Die: Protein! When it comes to the topic of sports nutrition there are many myths and fallacies that float around like some specter in the shadows. They pop up when you least expect them and throw a monkey wrench into the best laid plans of the hard training athlete trying to make some headway. What about Potassium? Information on potassiumWhen you read about potassium and senate document report 264 you'll life should be changed forever. You're going to discover that the biggest fallacy most people aren't aware of is that if we eat a balanced diet, (the four food groups), we get all the nutrients we need to stay healthy and live a long life. Dont Allow Your Food To Control You Food addiction isn't a problem. Pretending like you can't live without eating however, IS the problem. Soy Phytoestrogens and the Art of Propaganda In this newsletter we will discuss the current controversy about soy phytoestrogens. The established literature to date is replete with studies that find soy phytoestrogens beneficial to disease prevention including prevention of breast cancer. Heart Friendly Foods Heart disease results when plaque builds up inside the arterial walls, which causes a partial or complete obstruction of blood flow. This reduces flow of blood to heart and may result in angina. Being Proactive With Your Health Decisions In today's world, there's a definite need to be proactive in protecting our health. But that assumes there's something you CAN do to protect it. Dietary Sources of Glutathione DIETARY SOURCES OF GLUTATHIONE: Glutathione (GSH) is an antioxidant and detoxifying agent whose protective role has been demonstrated in numerous clinical studies. GSH is synthesized rapidly in the liver, kidneys, and other tissues of the body, including the gastrointestinal tract. Fluoride Damages Childrens Bones, Study Says White-spotted or yellow splotched teeth may reveal more than needed expensive cosmetic dentistry.Children with fluoride-discolored teeth (dental fluorosis) are more likely to have bone damage, according to a study published in the journal "Fluoride. Why Fad Diets Don't Work Fad diets have been around for more than 50 years and no matter how many come and go, we are always intrigued and excited by the next one feeling almost sure this will be the one to work. And they do work. Fighting Burn-out: Natural Help For Stress, Fatigue and Adrenal Insufficiency The adrenal or "stress glands" are small, triangular shaped glands located on the top of the kidneys. Their function is to prepare the body's resources to run or fight through the releasing of specific hormones. The Importance of Protein Protein is one of the basic building blocks of the body so it is an essential part of your diet and can influence your strength but probably not your energy. Your muscles are built with protein and in fact protein is made up of 20 amino acids.
|
|
home | site map Men's Health | Women's Health | Children's Health | Elder Health Holistic Health | Healthy Heart | Cancer | Weight Loss Exercise & Fitness | Healthy Resources |
|
|
